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In pharmacology, GABA A receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor ... Abstract. An appreciation of the structure and function of the GABA A-benzodiazepine receptor-chloride ionophore complex is necessary in order to understand the ... The hypothesis that agonist ligands of the central benzodiazepine (BZ) receptor contribute to the manifestations of hepatic encephalopathy (HE) by enhancing the ... Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity. It serves as a central nervous system depressant and skeletal ... Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA A Receptor Modulators?

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